HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.
From Grants.gov — open and forecasted opportunities (grants.gov). First seen Oct 10, 2026.
Details
- Agency
- National Institutes of HealthFind in source ↗
- Closes
- Oct 30, 2026Find in source ↗
- Posted
- Sep 28, 2026Find in source ↗
- Opportunity number
- PAR-27-045Find in source ↗
- Assistance listing (ALN)
- 93.473; 93.273; 93.866; 93.846; 93.853; 93.121; 93.213; 93.286Find in source ↗
- Eligible applicants
- Special district governments; Public and State controlled institutions of higher education; Small businesses; Independent school districts; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; State governments; Native American tribal governments (Federally recognized); Private institutions of higher education; City or township governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments)Find in source ↗
- Eligibility notes
- Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.Find in source ↗
- Category
- HealthFind in source ↗
- Funding type
- GrantFind in source ↗
History
No changes since GrantScout first read this opportunity on Oct 10, 2026.
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