Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)
The purpose of this notice of funding opportunity (NOFO) is to identify modifiable mechanisms and therapeutic targets to address central nervous system (CNS) complications associated with human immunodeficiency virus (HIV). The initiative supports a phased research approach beginning with the identification of patient phenotypes characterized by convergent pathophysiological features, followed by the discovery and experimental validation of molecular mechanisms using innovative in-vitro and in-vivo models. The goal of this NOFO is to advance therapeutic target, and intervention discovery to address the multifactorial and heterogeneous nature of HIV-associated CNS dysfunction.
From Grants.gov — open and forecasted opportunities (grants.gov). First seen Oct 10, 2026.
Details
- Agency
- National Institutes of HealthFind in source ↗
- Closes
- Oct 28, 2027Find in source ↗
- Posted
- Sep 30, 2026Find in source ↗
- Opportunity number
- RFA-MH-27-125Find in source ↗
- Assistance listing (ALN)
- 93.853; 93.242; 93.279Find in source ↗
- Eligible applicants
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; County governments; Independent school districts; Special district governments; State governments; For profit organizations other than small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Small businesses; City or township governments; Others (see text field entitled "Additional Information on Eligibility" for clarification)Find in source ↗
- Eligibility notes
- Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.Find in source ↗
- Category
- HealthFind in source ↗
- Funding type
- GrantFind in source ↗
History
No changes since GrantScout first read this opportunity on Oct 10, 2026.
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