Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)
The purpose of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to advance the discovery of biological processes and disease mechanisms mediated by somatic mutations in human tissues. Since 2023, the program has generated multi-omic somatic mutation datasets from a standardized set of human tissues spanning all three germ layers. Building on the Stage 1 foundation, the NIH intends to issue a Notice of Funding Opportunity (NOFO) seeking support for Stage 2 of the SMaHT Genome Characterization Centers (GCCs) initiative. The SMaHT Stage 2 GCCs will determine the functional consequences of somatic mutations in healthy and clinically relevant tissue samples, the latter comprising patients whose phenotype is suspected to be driven by somatic mutations. This work will support the SMaHT Network's efforts to characterize somatic mosaicism and its role in human biology and disease.
From Grants.gov — open and forecasted opportunities (grants.gov). First seen Oct 10, 2026.
Details
- Agency
- National Institutes of HealthFind in source ↗
- Posted
- Sep 14, 2026Find in source ↗
- Opportunity number
- RFA-RM-28-015Find in source ↗
- Assistance listing (ALN)
- 93.310Find in source ↗
- Eligible applicants
- County governments; Private institutions of higher education; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; City or township governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); State governments; Small businesses; Independent school districts; Special district governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; For profit organizations other than small businesses; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationFind in source ↗
- Eligibility notes
- Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).Find in source ↗
- Category
- HealthFind in source ↗
- Funding type
- Cooperative AgreementFind in source ↗
History
No changes since GrantScout first read this opportunity on Oct 10, 2026.
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